Bone marrow metastasis

Abstract:
Many malignant tumors can potentially metastasize to the bones. However, this occurs most frequently in carcinomas of the breast, lung, kidney, thyroid and prostate glands. Most bone metastases are osteolytic. Affected areas radiographically show less bone density. Osteoblastic metastases typically occur with carcinomas of the prostate or breast.

Clinical picture:
Bone metastases can lead locally to pain. Pathological fractures (absence of trauma) occur in osteolytic metastases.

Hematology:
In advanced metastases of bone marrow, bone marrow insufficiency with pancytopenia or a leukoerythroblastic blood picture may occur. The occurrence of a microangiopathic picture is observed especially in bone marrow metastases of stomach carcinomas.

Bone marrow:
Bone marrow metastases typically manifest themselves in films as epithelial growths.


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