Target cells

Definition:

Target cells demonstrate an accumulation of hemoglobin within the central pallor, which gives them a target-like appearance.

Occurrence:
Target cells result from a disparity between the hemoglobin content (low) and cell surface (large). They can be observed in thalassemia (frequent), HbC-disease, other hemoglobinopathies, iron deficiency anemia, after splenectomy, and in liver disease.