Platelets of variable size

Definition:

This refers to size variations existing between platelets.

Occurrence:
Platelets of variable size are usually an indication of increased megakaryocytopoiesis. They typically occur with increased platelet consumption (e.g. immune thrombocytopenia) and with increased autonomous production (essential thrombocythemia). Platelets of variable size are congenitally present in the May-Hegglin anomaly.